PHS self-reports 9A to 9Z

UW-Madison's
PHS self-reports
9A to 9Z

9A
2/25/2019

"... OLAW understands that a nonhuman primate received two challenges with simian immunodeficiency virus, though the protocol was approved for only one. No adverse effects were reported for the animal."[!]

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."

9B
7/9/2019

"... OLAW understands that in late November 2018 while laboratory personnel were separating mice into new caging in a core facility [School of Medicine], they failed to remove a sticker that covered the outlet on one water bottle. The animals in that cage did not have access to water and two died mice died."

"... actions taken to resolve the issues and prevent recurrence were appropriate."

9C
4/23/19

"... OLAW understands that a monkey cage door had not been appropriately locked by staff and two animals escaped into the room. They fought with other monkeys in the room and one sustained a finger injury and one sustained a tongue injury. Another caged monkeys also sustained a tongue injury."

"... OLAW understands that measures have been implemented to correct and reduce the likelihood of a recurrence of this problem."

9D
4/23/2019

"... OLAW understands that due to misidentification of the tattoos, one of two paired of cynomolgus monkeys was subjected to unnecessary anesthesia and analgesia.

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."

9E
4/9/2019

"... OLAW understands that two mouse pups in separate cages were found trapped between the wire lid and cage top. The mice had no access to water and one died. This incident occurred following weaning of the mice by laboratory staff."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

9F
6/17/2019

"... OLAW understands that six live neonatal mice were found in the carcass freezer due to a failure to ensure death after asphyxiation with CO2 for euthanasia. The required secondary physical method had not been used.

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

9G
7/22/2019

"... OLAW understands that a marmoset sustained a broken femur during approved protocol manipulations."

"...OLAW understands that measures have been implemented to address this adverse event."

This event led to the the university being cited for a Critical violation of the Animal Welfare Act on 7/9 by USDA/APHIS. The marmoset seems to have struggle so intensely when being restrained while was being done to them that they broke their leg. The leg was injured to such a degree that it was amputated.

9H
6/17/2019

"... OLAW understands that following an approved eye procedure in a rabbit, no documentation was made regarding postprocedural monitoring or administration of analgesia."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

9I
6/17/2019

"... OLAW understands that 18 mice had escaped their cages by chewing through the hole for the water bottle. A research technician had removed the bottles to replace them but was gone for several hours.

The corrective action consisted of catching 16 mice and placing them in a clean cage or euthanizing them. Two mice were not captured."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

9J
Duplicate/"does not exist" per DHHS

9K
7/8/2019

"... OLAW understands that a veterinary technician observed a wound in an adult macaque and inadvertently documented this finding and treatment plan in the enclosure mate's medical record. As a result the wrong macaque received anti-inflamatory medication for two days which delayed treatment for the injured animal until the error was discovered. "

"... OLAW concurs with the actions taken by the institution and the IACUC to adhere to the PHS policy."

9L
7/8/2019

"... OLAW understands that an animal caretaker failed to properly lock an animal enclosure and a student animal caretaker responsible for checking the enclosure failed to identify the improperly attached lock. Three macaques sustained injuries that required veterinary intervention after two adult macaques exited their primary enclosure and after one of the two interacted with an animal still in his/her enclosure.

"... OLAW concurs with the actions taken by the institution and the IACUC to adhere to the PHS policy."

9M
7/17/2019

"... OLAW understands that five infant rhesus monkeys were subjected to behavioral tests at a different frequency than described in the approved protocol. The tests involved removing the infants from their mothers for one hour and conducting the testing. Conducting the tests three in a row rather than once per month resulted in better outcomes.

"The corrective action consisted in amending the protocol to reflect the actual testing schedule."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

Note: The correspondence in the case file describes a second violation left unremarked on by OLAW. The university reported: "... a veterinary technician inadvertently administered an incorrect dose of an anti-inflammatory (meloxicam) to an infant rhesus macaque after identification tattoos were place on its ears."

9N
7/17/2019

"... OLAW understands that a greater than approved dose of an anti-inflamatory agent was inadvertently given to an infant macaque.

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

9O
12/10/2019

"... This Office understands that the SMPH IACUC determined that instances of noncompliance occurred with respect to: researchers use of expired buprenorphine on a group of mice during protocol-approved procedure.

"... OLAW understands that the University of Wisconsin-Madison has implemented appropriate measures to correct and prevent recurrences of this problem and is now compliant with provisions of the PHS Policy."

9P
10/28/2019

"... OLAW understands that in late August, 2019, an adult marmoset received an overdose of an anti-inflammatory agent due to an error by a veterinary technician."

"The prompt consideration of this matter by the University of Wisconsin - Madison was consistent with the philosophy of institutional self-regulation. Similarly, the actions taken to resolve the issue and prevent recurrence were appropriate."

9Q
10/28/2019

"... OLAW understands that on September 19, 2019, an adult rhesus monkey was injured in its cage by another rhesus that had escaped its enclosure. An animal caretaker had not placed a lock on one of the doors of the enclosure. The injuries required veterinary attention."

"The prompt consideration of this matter by the University of Wisconsin - Madison was consistent with the philosophy of institutional self-regulation. Similarly, the actions taken to resolve the issue and prevent recurrence were appropriate."

9R
10/28/2019

"... OLAW understands that on August 28,two macaques sustained injuries that required veterinary attention after they removed the divider separating their home enclosures. The incident occurred after two animal caretakers had not placed a lock on the divider...".

"The prompt consideration of this matter by the University of Wisconsin - Madison was consistent with the philosophy of institutional self-regulation. Similarly, the actions taken to resolve the issue and prevent recurrence were appropriate."

9S
12/11/2019

"... This Office understands that the SMPH IACUC determined that instances of noncompliance occurred with respect to administration of a compound, fisetin, to a group of mice prior to protocol approval.

"... OLAW understands that the University of Wisconsin-Madison has implemented appropriate measures to correct and prevent recurrences of this problem and is now compliant with provisions of the PHS Policy."

9T
12/16/2019

"... OLAW understands that a rhesus monkey escaped its cage because it had not been properly locked. The monkey fought with another one and both sustained mild injuries."

"... OLAW understands that measures have been implemented to correct and reduce the liklihood of a recurrance of the problem."

9U
12/16/2019

"... OLAW understands that an infant rhesus monkey was given an expired antibiotic for four days for diarhea."

"... OLAW understands that measures have been implemented to correct and reduce the liklihood of a recurrance of the problem."

9V
3/2/2020

"... OLAW understands that mice were given an antibody not described in the approved protocol and two mice died and one required euthanasia."

"The corrective actions consisted of stopping administration of the antibody, amending the protocol to include the anitbody at a reduced dose from what had been been given, and retraining laboratory staff on protocol compliance.

"... OLAW understands that measures have been implemented to correct and prevent recurrance of this problem."

9W
3/10/2020

"... OLAW understands the following about the incidents and the corresponding corrective actions:

A transport cage was not fully secured on a lift which allowed the rhesus monkey to escape and fight with other monkeys resulting in injuries.

Corrective action: The injured animnals were treated and the lift was altered to make it more stable.

An animal care taker failed to provide water to a rhesus monkey on two consecutive days. No adverse clinical signs were noted.

Corrective action: The caretaker was retrained on appropriate provision of water."

"... OLAW understands that measures have been implemented to correct and prevent the liklihood of a recurrance of these problems."

9X
3/9/2020

[Duplicate of 9W]

9Y
3/13/2020

"The Office of Laboratory Animal Welfare (OLAW) acknowledges receipt o[-your February 26, 2020 letter reporting an instance of noncompliance with the PHS Policy on humane Care and Use of Laboratory Animals at the University of Wisconsin - Madison. According to the information provided, OLAW understands that 36 mice died after being infected with a wild-type herpes virus (HSV-l). It was determined that a mathematical error was made in the dosing calculations resulting in the animals receiving a higher dose than intended, The remaining 64 animals on the study were euthanized due to the compromised experiment. The animals were supported by an NW grant.

The lab has instituted new preventive measures wherein no single person can infect animals without confirming with the PI that their dosing calculations are correct and that the stocks of virus being used have been properly diluted."

9Z
5/8/2020

"OLAW understands that two marmosets were given an experimental drug orally although the approved protocol stated that the intravenous or intramuscular route would be used. [The drug was Tacrolimus. It was first approved in 1994. RB]

"OLAW understands that measures have been implimented to correct and prevent recurrance of this problem."