Monday, January 20, 2020

UW-Madison's Self-Reported Animal Welfare Violations

These pages are a set of links to correspondence between the University of Wisconsin, Madison and the National Institutes of Health (NIH) Office of Laboratory Animal Welfare (OLAW) concerning violations of the Public Health Service (PHS) Policy on the Humane Care and Use of Laboratory Animals.

NIH/OLAW rarely inspects laboratories. NIH/OLAW's oversight is primarily a matter of talking to a lab's representatives on the phone and responding to letters from them reporting on their violations and what they did in response.

PHS self-reports 3N to 3Z

PHS self-reports 4A to 4Z

PHS self-reports 5A to 5Z

PHS self-reports 6A to 6Z

PHS self-reports 7A to 7Z

PHS self-reports 8A to 8Z

PHS self-reports 9A to 9U

The lists are ordered by OLAW Case Number; in some instances the date on the OLAW response letter is out of sequence. Brief excerpts from OLAW's response letter are provided; a review of each file will provide additional detail. A handful of the reports are missing in my records. If I get them, I will put them in their appropriate spot in an effort to complete the record.

The entries are listed in this fashion:

OLAW Case Number
Date of OLAW response
OLAW's summary
OLAW's resolution

All laboratories using vertebrate animals in Public Health Service-funded research are required to periodically submit a document to NIH promising to adhere to Public Health Service (PHS) Policy on the Humane Care and Use of Laboratory Animals. This document is referred to as the entity's
"Animal Welfare Assurance." The correspondence is marked:

re: Animal Welfare Assurance
A3368-01 [OLAW Case Number]

A3368-01 is the University of Wisconsin, Madison's PHS Assurance number.

It is hard to find evidence of meaningful oversight in this correspondence because similar accidents, screw-ups, and violations occur repeatedly, and in every case OLAW answers with some version of: "OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

PHS self-reports 3N to 3Z


UW-Madison's
PHS self-reports
3N to 3Z


3N
4/11/2012

"... OLAW understands that on sixteen occasions anesthesia recovery records for nonhuman primates were not completed promptly or correctly and animals were not being checked regularly."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

3O
4/11/2012

"... OLAW understands that thirteen mice received a higher dose of an experimental drug than described in the approved protocol over a period of several days."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

3P
4/11/2012

"... OLAW understands that [10] mice failed to receive post-operative analgesics as described in the approved protocol."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

3Q Missing

3R Missing

3S
4/11/2012

"... OLAW understands that a female rhesus macaque with infant had been left in a transport cage for an undetermined amount of time (1 day or more) following the conduct of an approved blood draw."

"...OLAW understands that measures have been implemented to correct and prevent the occurrence of this problem."

3T
4/30/2012

"... OLAW understands that a total of 45 adult and juvenile mice drowned after their cages filled with water due to an improperly docked cage which caused continuous activation of the lixit. Human error involving a different individual from the same laboratory caused the same problem previously..."

"...OLAW understands that measures have been implemented to correct this problem."

3U Missing

3V
4/17/2012

"... OLAW understands that two nonhuman primates on an approved fluid regulation study failed to receive their minimum daily fluid allotment on numerous occasions…. Also, a student working with the primates was not listed on the protocol."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

3W
4/18/2012

"...OLAW understands the following about the incidents and the corresponding corrective actions: 1) A marmoset was used in a terminal profusion although this had not been described in the approved protocol. 2) An anesthetized cynomolgus monkey undergoing an approved MRI procedure sustained skin burns on its legs from the warming bags used to maintain body. 3) A rhesus monkey failed to receive water due to a miscommunication between research and animal care staff. 4) Blood samples were taken from a cynomolgus monkey although the approved protocol only described the procedure for a rhesus monkey."

"... OLAW is satisfied that appropriate actions have been taken in all three instances to investigate, correct, and prevent recurrence of the noncompliance."

3X
4/17/2012

"... OLAW understands that a water pipe froze and burst in an animal building and flooded 25 rooms. Some animals became wet but none sustained injuries or died."

"... OLAW understands that measures have been implemented to correct and prevent the occurrence of this problem."

3Y
3/13/2011

"… OLAW understands that the Letters and Science Animal Care and Use Committee (ACUC) did not conduct the fall 2011 semiannual facility inspection at a remote facility due to a failure to schedule a consultant to conduct the visit."

"... OLAW is satisfied that appropriate actions have been taken in all three instances to investigate, correct, and prevent recurrence of the noncompliance."

3Z
4/11/2012

"... OLAW understands that a cow used in a teaching protocol was subjected to a Caesarean section surgical procedure that had not been described in the approved protocol."

"... OLAW is satisfied that appropriate actions have been taken to investigate and prevent recurrence of the noncompliance."

PHS self-reports 4A to 4Z

UW-Madison's
PHS self-reports
4A to 4Z

4A
4/14/2012

"... OLAW understands the following about the incidents and the corresponding corrective actions: 1) A cage was not securely seated in the rack causing a lixit to leak into lower cages, resulting in the drowning deaths of 19 mice. Corrective action: All lixit nozzles were replaced with shielded water tips on all racks in the facility. 2) A rat was given repeated doses of pentobarbital due to difficulty in anesthetizing the animal. The individual performing the procedure was directed to euthanize the rat ... Intracardiac injection had not been approved in the protocol."

"... OLAW understands that measures have been implemented in both situations to correct and prevent recurrence of the problem."

4B
4/30/2012

"... OLAW understands that a significant change was made to a training protocol without prior approval from the Animal Care and Use Committee. Specifically, rats undergoing non-survival surgery were given saline instead of buprenorphine pre-operatively which constituted a significant change."

"... OLAW is satisfied that appropriate actions have been taken to correct and prevent the occurrence of this problem."

4C
7/18/2012

"... OLAW understands that an anesthetized cat undergoing surgery sustained a skin burn from the heating blanket."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

4D
4/30/2012

"... OLAW understands that two infant macaques failed to receive water for one day (although they dad received formula) and a mother with infant in the nursery also failed to receive water."

"... OLAW understand that measures have been implemented to prevent recurrence of this problem."

4E
7/14/2012

"... OLAW understands that a student failed to conduct the daily health check for two frogs for one day. The following day one frog was dead and the other lethargic. The conduct of heath checks was not being documented by the students."

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."

4F
5/15/2012

"OLAW understands that 10 mice received tail snips without anesthesia when the were older than 21 days of age."

"OLAW is satisfied that appropriate actions have been taken to investigate this incident."

4G
6/19/2012

"... OLAW understands that five mice on a food restriction study were provide double their food supply on one day and none the next."

"... OLAW understands that measures have been implemented to correct and prevent the occurrence of this problem."

4H
9/12/2012

"... OLAW understands that an anesthetized rhesus monkey was not being observed at the interval described in the approved protocol. Problem with adequate staffing during the procedure contributed to the problem."

 "... OLAW understands that measures have been implemented to  prevent the recurrence of this problem."

4I
6/19/2012

"... OLAW understands that a young rhesus monkey died of suffocation after having its head trapped between the cage and squeeze back support."

"No preventative action can be taken as this was an unanticipated accident initiated by the animal's own behavior."

4J
6/12/2012

"... OLAW understands that four mice failed to receive a water bottle on their cage after being weaned."

 "...OLAW understands that measures have been implemented to prevent the recurrence of this noncompliance."

4K
8/8/2012

 "... OLAW understands that an anesthetized macaque sustained a burn from a heating bag used with a heating blanket to maintain body heat."

 "... OLAW understands that measures have been implemented to prevent the recurrence of this noncompliance."

4L
8/8/2012

 "... OLAW understands that two adult male rhesus monkeys sustained scratch wounds due to fighting after an animal caretaker inadvertently removed the divider between the two cages."

"... OLAW is satisfied that appropriate actions have been taken to investigate and prevent recurrence of the problem."

4M
8/22/2012

 "... OLAW understands that an anesthetized sheep undergoing surgery died due to a close pop-off valve on the anesthetic machine."

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."


4N
9/27/2012

"... OLAW understands that the daily health check for a group of mice was not performed for one day."

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."


4O
8/29/2012

"... OLAW understands that a lesion was created in the aorta of a pig although the approved protocol did not include this anatomical site."

"... OLAW is satisfied that appropriate actions have been taken to correct and prevent this recurrence of this noncompliance."

4P Missing

4Q
11/2/2012

"... OLAW understands the following about the incidents...: 1) A male and female rhesus monkey were inadvertently paired  and the female sustained a laceration. The male was subsequently given a higher dose of [an] anti-inflammatory drug  than required due to a misidentification of the animal. 2) A monkey escaped and two monkeys entered the same enclosure after pushing out a floor pan door and cage divider because locks had not been attached as required. One of the animals sustained injuries."

"... OLAW understands that measures have been implemented in both situations to prevent recurrence of the problem."

4R
12/5/2012

"... OLAW understands that laboratory staff performed a C-section on a mouse experiencing dystocia [difficult birth]. The surgery was not described in the protocol and was not authorized by the veterinary staff.

"... OLAW is satisfied that appropriate actions have been taken to investigate and prevent recurrence of the noncompliance."

4S Missing

4T
12/12/2012

"... OLAW understands that a student failed to promptly euthanize three mice with tail wounds as directed by the veterinarian. The mice were euthanized six days later."

 "... OLAW understands that measures have been implemented in both situations to prevent recurrence of the problem."

4U
2/11/2013

"... OLAW understands that 150 more mice were used than approved on the protocol."

"... OLAW is satisfied that appropriate actions have been taken to correct and prevent recurrence of this problem."

4V Missing

4W
9/13/2013

 "The Office of Laboratory Animal Welfare (OLAW) acknowledges receipt of your September 16, 2013 letter providing an update on a previously reported and closed problem with livestock feed at the University of Wisconsin-Madison. Pig and chicken diet prepared at a University feed mill was low in calcium. To ensure quality control of feed, a feed mill committee was formed, new standard operating procedures were established, and a new mill manager was to be hired. 
         '
"... OLAW understands that measures have been implemented to correct and prevent occurrence of the original problem."

4X
2/26/2013

"... OLAW understands that three cynomolgous monkeys were challenged with a viral dose that was one logarithm greater that the amount described in the approved protocol."

"... OLAW understands that measures have been implemented to correct this problem."

4Y Missing

4Z
5/9/2013

"... OLAW understands that a cow accidentally slipped into the auger channel in the automatic manure handling system and was severely injured.

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

PHS self-reports 5A to 5Z


UW-Madison's
PHS self-reports
5A to 5Z

5A
5/5/2013

"According to the information provided, a research staffer administered anesthetic to a mouse whose leg was swollen after becoming caught in the cage wire. The individual failed to notify the veterinarian about the injury or the administration of the drug."

"... OLAW is satisfied that appropriate actions have been taken to investigate and prevent recurrence of the noncompliance."

5B
2/26/2013

"... OLAW understands that a marmoset died while under anesthesia due to a veterinary technician closing  a port on the endotracheal tube which caused pneumothorax. Also, the anesthesia machine used was nor appropriate for this procedure." 

"... OLAW understands that measures have been implemented to  prevent recurrence of this problem."

5C Missing

5D
3/11/2013

"... OLAW understands that a rhesus monkey received an overdose of anesthesia based on body weight because the veterinary student responsible failed to verify the animal's identification."

"... OLAW understands that measures have been implemented to prevent recurrence of the problem."

5E
3/7/13

"... OLAW understands that two anesthetics used during a terminal pig surgery had not been described in the approved protocol."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

5F
3/13/2013

"... OLAW understands that several mice over 28 days of age were subjected to tail biopsies without anesthesia."

"OLAW understands that the protocol was not PHS-supported, but concurs that the incident was serious and concurs with the actions taken by the Animal Care and Use Committee.

5G
4/29/2013

"... OLAW understands that 15 mice died of suffocation after being transported between facilities in  cardboard containers without adequate ventilation."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

5H
5/29/2013

"... OLAW understands that one rat was subjected to glaucoma surgery in both eyes although the approved protocol described the procedure for only one eye."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

5I
12/18/2013

 "... OLAW understands that two additional rhesus monkeys were determined not to have received analgesia per protocol after being injected with subcutaneously with [redacted].

"... OLAW is satisfied that appropriate action was taken to investigate, correct, and prevent recurrence of the noncompliance."

5J
6/24/2013

"... OLAW understands that a young macaque died of asphyxiation after pulling a chain, holding an enrichment device, into the cage and wrapping it around its neck."

"... OLAW understands that measures have been implemented to prevent recurrence of the problem."

5K
11/20/2013

"... OLAW understands that several rats did not have access t water over a three day weekend because the bottles had been turned over to avoid leakage during cage transport."

 "... OLAW understands that measures have been implemented to prevent recurrence of this problem."

5L
6/24/2013

 "... OLAW understands the following about the incidents...: 1) Due to a transposition of animal weights by a veterinary technician, one nonhuman primate received an overdose of an anesthetic and reversal agent, while the other monkey was under-dosed with the drugs.... 2) A monkey broke its cage lock and escaped. 3) Two adult male macaques sustained fight injuries due to engaging eachother through an open cage divider. The animal caretaker had  failed to lock the divider and did not notice the problem during the cage checks."

"Both animals were treated, but one was euthanized under anesthesia due to cardiopulmonary depression." [Neither Google nor either of my two medical dictionaries mention "cardiopulmonary depression."]

"... OLAW understands that measures have been implemented in each situation to prevent recurrence of the problem."

5M
8/7/2014

"... OLAW understands that a jugular cut-down procedure was performed on an anesthetized pig to obtain blood although this procedure was not described on the approved protocol."

"... OLAW is satisfied that appropriate action was taken to investigate and prevent recurrence of the noncompliance."

5N
8/22/2014

"... OLAW understands that a zebra finch broke its leg after flying into the waste pan under the cage as it was being cleaned."

"OLAW concurs with the actions taken to address the situation..."

5O
10/31/2014

"... OLAW understands that two heifers drowned after gaining access to a manure pit."

 "... OLAW understands that measures have been implemented to prevent recurrence of this problem."

5P
10/31/2014

 "... OLAW understands that an individual was working with zebra fish for an extended period of time but had not been listed on the approved protocol."

 "... OLAW understands that measures have been implemented to prevent recurrence of this problem."

5Q Missing

5R Missing

5S
10/31/2014

"... OLAW understands the following about the incidents...: 1) Laboratory staff failed to provide a daily health check on 34 ground squirrels. 2) Two rats died from an overdose of anesthetic. Because the animals were were slow to achieve a surgical plan[e] of anesthesia, the laboratory staff administered additional doses of [the] drug although this had not be[en] approved in the protocol."

"... OLAW is satisfied that appropriate action was taken to investigate, correct, and prevent recurrence of the noncompliance."

5T
10/31/2013 [sic]

"... OLAW understands that two nonhuman primates were able to escape their cage because the lock had been incorrectly placed allowing the animals to open it. One monkey sustained hand wounds which required two partial digit amputations."

 "... OLAW understands that measures have been implemented to prevent recurrence of this problem."

5U
11/22/2013 [sic]

 "... OLAW understands the following about the incidents...: 1) on two separate occasions, two macaques sustained skin burns due to exposure to an intermittently malfunctioning heat lamp. 2) One macaque escaped its cage and injured its toes.  No problem was identified with the cage. A second  macaque died due to internal bleeding while undergoing an ultrasound guided liver biopsy.

"... OLAW understands that measures have been implemented in all situations to correct and prevent recurrence of the problem."

5V
1/3/2014

"... OLAW understands that one monkey escaped its cage by bending open the door and then bit another monkey's tongue."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

5W
12/11/2013 [sic]

"... (OLAW) acknowledges receipt of your December 9, 2013 letter reporting the suspension of three animal activities at the University of Wisconsin-Madison. OLAW understands that the School of Veterinary Medicine Animal Care and Use Committee (ACUC) took this action after determining that an investigator failed to submit protocol renewals in a timely fashion despite receiving numerous reminders. The protocols involved teaching activities using large animals."

"OLAW understands that the research was not PHS-supported but concurs that the incident was serious and supports the actions taken by the ACUC."

5X Missing

5Y
8/5/2014

"... OLAW understands the following about the incidents...: 1) a rhesus monkey failed to receive a single daily dose of post-operative antibiotics due to a failure to schedule the procedure by a veterinary technician. 2) A PET scan was performed on a monkey outside the time-frame described in the approved protocol."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

5Z
8/5/2014

"... OLAW understands that a ground squirrel was administered an experimental radio-isotope by oral gavage although the approved protocol stated that this was to be given by intraperitoneal injection."

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."



PHS self-reports 6A to 6Z


UW-Madison's
PHS self-reports
6A to 6Z

6A
8/25/2014

"... OLAW understands that four mice sustained dehiscences [reopening] of their cranial incision sites."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

6B
4/25/2014

 "... OLAW understands that two mice died and three required euthanasia after recieving an overdose of an anesthetic."

"... OLAW is satisfied that appropriate actions have been taken to investigate and prevent recurrence of the noncompliance."

6C
4/22/2014

"... OLAW understands that over a period of several months four rabbits received expired  anesthetics, analgesics, and euthanasia solution."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

6D
3/27/2014

"... OLAW understands that a male macaque sustained mild facial injuries after escaping from its cage which had not been locked by the animal care staff."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

6E
4/25/2014

"... OLAW understands that two mice died and four required euthanasia after developing peritonitis caused by non-sterile intraperitoneal injection of a drug."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

6F
4/25/2014

"... OLAW understands that a field study on sloths included attachment of radio collars to the animals although this activity had not been described in the approved protocol."

"OLAW understands that the research was not PHS-supported but concurs that the incident was serious and supports the actions taken by the ACUC."

6G
4/29/2014

"... OLAW understands that a nonhuman primate escaped its cage after a student failed to follow standard operating procedure regarding appropriate locking of the cage. Although the animal sustained no injuries another monkey bit its cage mate in response to the escape."

"... OLAW understands that measures have been implemented to reduce recurrence of this problem."

6H
5/20/2014

"... OLAW understands that twelve mice died unexpectedly following surgery. ... The cause of death was not determined."

"... OLAW understands that measures have been implemented to reduce the likelihood of recurrence this problem."

6I
5/20/2014

"... OLAW understands that due to switched cage cards the wrong dog was used on an imaging procedure. The laboratory staff failed to verify the identity of the dog prior to use. The activity included anesthesia, catheterization, blood draw, and imaging."

"... OLAW is satisfied that appropriate actions have been taken to investigate and prevent recurrence of the noncompliance."

6J
5/28/2014

"... OLAW understands that a rhesus monkey sustained an injury from another monkey after moving the divider between the cages. The panel had not been properly secured by the animal caretakers."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

6K
6/6/2014

"... OLAW understands that mice received a different post-operative analgesic than described in the approved protocol."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

6L
8/15/2014

"... OLAW understands that young turkeys and chickens on a nutrition study experienced slow growth and unexpected mortality due to low levels of micronutrients in the feed."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

6M
11/18/2014

"... OLAW understands that 10 young quail died or required euthanization after  undergoing poorly performed debeaking procedures."

 "... OLAW understands that measures have been implemented to correct and prevent recurrence of the problem."

6N
8/5/2014

"... OLAW understands that steers on a pasture feeding trial experienced bloat and were treated for two days with an outdated bloat drug after the unexpired supplement was depleted."

"OLAW understands that the problem was corrected."

6O
9/18/2014

"... OLAW understands that goats were given feed with a calcium-phosphorus ratio with too little calcium. Two goats developed obstructive urolithiasis and were euthanized. Ultrasound evaluation revealed bladder stones in other goats.... This activity was not PHS funded."

"OLAW is satisfied that appropriate actions have been taken to investigate these incidents and the additional actions taken to prevent recurrence are appropriate."

6P Missing

6Q Missing

6R
8/4/2014

"... OLAW understands the following...: 1) An anesthetized cynomolgus monkey was being carried by a technician when another caged animals grabbed and bit its tail. ...The tail tip was amputated... 2) A macaque was inadvertently fasted for one day because a food deprive tag had been left on the cage. 3) ... OLAW understands that five treatments for nonhuman primates were not performed due to human error by the technician. The treatments were for arthritis and a gastrointestinal problem ...

"... OLAW understands that measures have been implemented to correct and prevent recurrence of the problem."

6S
8/18/2014

"... OLAW understands that mice failed to receive post-operative analgesia as described in the protocol."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

6T
8/15/2014

"... OLAW understands the following...: 1) A rhesus monkey escaped its cage while being moved to a clean cage and sustained injuries to its cheek and finger. The finger required a partial digit amputation... 2) two marmosets which had been removed from their cage for dosing and blood collection were put back into the wrong cage, fought with the other animals, and one sustained a mild injury."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of these problems."

6U
11/17/2014

"... OLAW understands the following...: 1) Two adult rhesus monkeys sustained skin wounds due to fighting after being placed into test cages that did not have a secured divider. ... 2) For over a three year period, 478 mice failed to receive analgesia following tumor transplant surgery."

"... OLAW understands that measures have been implemented in both situations to correct and prevent recurrence of the problem."

6V
11/17/2014

"... OLAW understands that five mice died and three required euthanasia after receiving fatty acids in ethanol gavage. The concentration of alcohol was not determined in advance and the mice died of ethanol toxicity.

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."

6W
11/21/2014

"... OLAW understands the following...: 1) Mice were being bred and genotyped although this activity had not yet been approved by the animal care and use committee. ... 2) Rats on a water restriction protocol were not given water on one day."

"... OLAW is satisfied that appropriate actions have been taken in both situations to investigate, correct, and prevent recurrence of the noncompliance."

6X
12/3/2014

"OLAW understands that eight monkeys did not have access to water over a weekend due to a laboratory staffer turning off the drinking water line rather than the pan flush water line."

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."

6Y Missing

6Z Missing

PHS self-reports 7A to 7Z


UW-Madison's
PHS self-reports
7A to 7Z

7A
3/3/2015

"... OLAW understands that a live research rat was found in the carcass freezer due to a failure to confirm death following exposure to isoflurane for euthanasia.

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

7B
1/5/2015

"... OLAW understands the following...: Two macaques sustained facial wounds from fighting after contacting one another after opening the cage divider. ... 2) A macaque inadvertently received two doses of an analgesic within minutes of each other because the research staffer did not know the treatment had already been given by the animal care staff."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance in both situations."

7C
3/11/2015

"... OLAW understands the following...: 1) Two rhesus monkeys escaped from their cage and injured three other monkeys in the room... 2) Mice were overcrowded in a cage in a CO2 chamber being used for euthanasia.

"... OLAW understands that measures have been implemented in both situations to correct and prevent recurrence of the problem."

7D Missing

7E Missing

7F Missing

7G Missing

7H Missing

7I
7/30/2015

"... OLAW understands the following...: 1) Two marmosets were inadvertently confined to their nest box for 17 hours after approved pair testing.... 2) Four macaques received a challenge inoculation of pathogenic SIV although this had not been described in the approved protocol.... 3) Mice older than 28 days were anesthetized and subjected to tail clipping but did not receive analgesia as per protocol."

 "... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance in all three situations of noncompliance."

7J
7/30/2015

"... OLAW understands that a cage of adult rats and pups were not checked daily and were found without water.

"Although the animals were not dehydrated, they were euthanized due to concern over using them in a study."

"OLAW concurs with the actions taken by the institution to comply with the PHS Policy on Humane Care and Use of Laboratory Animals."

7K
8/17/2015

"... OLAW understands that the animal [a female ferret] accidentally died after getting its head stuck in the cage door."

"The incident was considered an unusual accident and no further action was taken."

7L
11/5/2015

"... OLAW understands that nine rats on a water restriction protocol failed to receive water for one day and one animal died.

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

7M Missing

7N
11/20/2015

"... OLAW understands that the primate sustained thermal injuries to both thighs from a warm fluid bag used to provide heat during an MRI scan."

"As this was an accident, no further preventative measures were taken."

"OLAW concurs with the actions taken by the institution to comply with the PHS Policy on Humane Care and Use of Laboratory Animals."

7O Missing

7P
12/24/2015

"... OLAW understands that a macaque required euthanasia due to illness caused by lack of water resulting from a disconnected water line." [Three animals were affected.]

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

7Q
3/1/2016

"... OLAW understands that two Peromyscus californicus housed in an investigator managed procedure room were not checked over a weekend. One mice [sic] died and required euthanasia."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

7R
3/1/2016

"OLAW understands the following...: 1) A rhesus monkey escaped its cage after the lock failed. The loose monkey and four others sustained minor wounds while one monkey sustained serious injury to a finger." [The finger was amputated.]... 2) A marmoset failed to receive a second daily anesthetic dose following surgery.

"... OLAW understands that measures have been implemented in both situation to correct and prevent recurrence of the problem."

7S
10/13/2016

"... OLAW understands that twelve rats were subjected to a surgical jugular blood draw although this activity was not described in the approved protocol."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

7T
3/15/2016

"... OLAW understands that four mice died after being treated topically with an agent whose dose was incorrectly calculated." [Eight others were euthanized]

"... OLAW understands that measures have been implemented to correct and prevent recurrence of the noncompliance."

7U
10/27/2016

"... OLAW understands the following...: 1) Four mice died of dehydration because the sipper tube on the water bottle was too short... 2) Sixteen mice failed to receive analgesics following surgical pellet placement."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

7V
10/27/2016

"... OLAW understands that six mice died after receiving an experimental compound not approved in the protocol."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance.">

7W
6/8/2016

Correspondence with OLAW about the results of a campus-wide survey of labs performing survival surgeries on rodents. The university reported that few problem were discovered.


7X
10/20/2016 "According to the information provided, OLAW understand that five mice died due to lack of food. The mice were on a special diet and were inadvertently not fed."

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."



7Y
7/21/2016

"...OLAW understands the following...: 1) A sedated macaque sustained burns to its chest and abdomen due to a faulty MRI coil... 2) A single macaque failed to receive single dose of post-operative analgesia... 3) A macaque failed to receive one post-operative analgesic ...".

"... OLAW understands that measures were implemented to correct and prevent recurrence of the problem in each situation."

7Z
10/11/2016

"...OLAW understands that two undergraduate students conducted animal activities with mice [over an eighteen month period] that were not listed on the protocol. The students had not received institution-based training or approval."

"... OLAW understands that measures were implemented to correct and prevent recurrence of this problem."

PHS self-reports 8A to 8Z


UW-Madison's
PHS self-reports
8A to 8T

8A
10/13/2016

"... OLAW understands that a Peromyscus mouse on NSF funded study (IOS-1355163) escaped while being transferred to a procedure hood by a student. The mouse then hid in a hole in the wall.

"... OLAW understands that measures were implemented to correct and prevent recurrence of this problem."

8B
10/20/2016

"...OLAW understands the following...: 1) A power outage prevented staff from accessing the Wisconsin National Primate Research Center Electronic Health Records which resulted in missed treatments of nutritional supplements... 2) Two rhesus monkeys manipulated their cage and one escaped. Three other monkeys sustained minor injuries from fighting with the escaped animal."

"... OLAW understands that measures were implemented in both situations to correct and prevent recurrence of the problem."

8C
5/25/2017

"...OLAW understands that mice were used in a pilot study which involved injection of cells, however, the procedure was not described in the approved protocol."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

8D
2/13/2017

"... OLAW understands the following...: 1) Four monkeys failed to receive their daily water ration due to miscommunication between animal care staff... 2) A monkey sustained minor wounds after it escaped its cage when a part malfunctioned."

"... OLAW understands that measures have been implemented in both situations to correct and prevent recurrence of the problem."

8E
2/13/2017

"... OLAW understands the following...: 1) Two macaques removed the cage divider due to a broken lock which allowed them to come in contact and fight. One animal sustained an injury... 2) A macaque was subjected to an approved cerebrospinal fluid collection but was not given the required post-procedure analgesic."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

8F
3/14/2017

"...OLAW understands the following...: 1) A macaque was fasted for 30 hours due to a scheduling error.... 2) Two monkeys being treated for a skin infection failed to receive one of their twice daily doses of an analgesic."

"... OLAW is satisfied that appropriate actions have been taken to investigate, correct, and prevent recurrence of the noncompliance."

8G
5/31/2017

"...OLAW understands the following...: 1) Five mice died because no food had been placed in their cage following weaning.... 2) Eight rats died from lack of oxygen after the computer and controller of the hypoxia chamber malfunctioned...."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of these problems."

8H
5/25/2017

"... OLAW understands that a cage door was not properly locked, allowing a macaque to escape. The animal sustained a finger injury at this time."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."


8I
5/25/2017

"... OLAW understands that an infant macaque inadvertently received a dose of a non-steroidal inflammatory agent."

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."

8J
7/17/2017

"... OLAW understands...: 1) A macaque received an additional analgesic dose due miscommunication between veterinary and research staff. ... 2) Two marmosets were misidentified and placed in cages with other marmosets and fighting occurred which caused injuries to both animals. ... 3) A macaque escaped its enclosure due to equipment failure, entered another enclosure, and fighting occurred which caused injuries to both animals. ... 4) A macaque received an intracranial dose of expired contrast agent..."

"... OLAW understands that measures have been implemented in each situation to correct and prevent recurrence of the problem."

8K
8/29/2017

"... OLAW understands that 20 rats died due to a power outage which impacted the ventilated racks...."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of the problem."

8L
12/7/2017

"... OLAW understands that a marmoset's foot was accidentally injured in its enclosure door."

8M
4/24/2018

"... OLAW understands that two rats died in a hypoxia chamber after an oxygen sensor failed and the chamber filled with nitrogen."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

8N Missing

8O
3/7/2018

"OLAW understands the following...: 1) Two marmosets escaped their cages because the door was not completely locked and one animal sustained a small hand laceration. ... 2) Two macaques escaped their cage after the attached tunnel came off and one animal was injured. Two other animals in the room were also injured by the escapees. ... 3) A macaque was given a contrast agent although this had not been described in the approved protocol. ..."

"... OLAW understands that measures have been implemented in each situation to correct and prevent recurrence of the problems."

8P
5/3/2018

"... OLAW understands that on two different occasions two different rhesus monkeys received expired valium..."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

8Q
4/23/2018

"... OLAW understands that three mice died and two were in poor condition after not receiving food after weaning. A second cage also had no food but the mice were in good shape."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

8R
7/7/2018

"... OLAW understands that on two separate occasions, two different macaques received an expired analgesic/sedative drug."

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."

8S
5/7/2018

"... OLAW understands that on two days in a row more blood was taken from a macaque than was approved in the protocol."

"... OLAW understands that measures have been implemented to prevent recurrence of this problem."

8T
5/7/2018

"... OLAW understands that an animal caretaker failed to lock a cage divider which allowed two macaques to escape and one became injured."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

8U
6/11/2018

"... OLAW understands that due to an unexpected lock failure on a primate cage, an animal escaped and sustained injuries.

"... OLAW understands that measures have been implemented to correct this problem."

8V
9/17/2018

"... OLAW understands the following about the incidents and the corresponding corrective actions:

1) One macaque sustained an injury after the divider between two cages broke and the animals were in contact.
2) Three infant macaques failed to receive their nightly feeding because the caretaker did not arrive.
3) One monkeys failed to receive the evening post-operative analgesic treatment because the same caretaker as in #2 did not arrive. The supervisor also failed to confirm that evening treatments had been given.

"... OLAW understands that measures have been implemented in all three situations to correct and prevent recurrence of this problem."

8W
11/5/2018

"... OLAW understands that a live mouse pup was found in the carcass refridgerator due to a failure to confirirm death following exposure to CO2. The required secondary physical method had not been applied."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

8X
11/5/2018

"... OLAW understands that due to human error, one macaque incorrectly received 19 days of joint treatment while the animal that needed the drug did not receive it for that length of time. The monkey needing treatment was reportedly not displaying signs of pain or distress. Two other monkeys on the same treatment regimen correctly received the drug."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

8Y
11/6/2018

"... OLAW understands that three macaques failed to recieve water over a three-day weekend due to a discrepancy between the computer records and the instructions at the animal room. There were reportedly no problems with the aniamls."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."

8Z
11/20/2018

"... OLAW understands that a marmoset escaped its cage during feeding and was not noticed by the animals caretaker. When the animal was captured, it was inadvertently placed in the wrong cage with other marmosets and sustained injuries."

"... OLAW understands that measures have been implemented to correct and prevent recurrence of this problem."