Friday, September 23, 2011

Professors London and Jentsch trying to fool the public (again)

> UCLA Newsroom > All Stories > News Releases
Professors London and Jentsch describe their addiction research
By UCLA Newsroom July 25, 2011
This is too ridiculous not to comment on:
What are our ethical principles?

When it comes to animal research, our ethical principles have two dimensions. First, we embrace — not simply accept — the Animal Welfare Act and the regulatory mechanisms that ensure that animal welfare is a key concern in designing and undertaking animal studies. We use the fewest animals possible and the least harmful methods. We do everything possible to avoid causing pain or distress in our studies, and we alleviate it using state-of-the-art methods when we can.

Second, it is our ethical obligation to pursue studies that may alleviate the suffering caused by methamphetamine addiction. Human suffering is real; it is all around us. It is ultimately avoidable, if we understand the problem deeply enough. We believe that people suffering from addictions and the people that love them deserve that every reasonable effort be made to address their problem, and we will, consequently, continue our work.
Here's an excerpt from something I wrote about Jentsch a few years ago:
In a paper from 2008, this monster explains:
Young adult male or female St Kitts green (vervet) monkeys (Chlorocebus aethiops sabaeus) at the St Kitts Biomedical Research Foundation (St Kitts, West Indies) were used. As the subjects were feral monkeys, their exact age was not known. These studies were approved by the relevant institutional animal care and use committee. Monkeys, housed individually in squeeze-cages, were injected with PCP twice daily for 14 days, as described before (Jentsch et al, 1997).… John D Elsworth, J David Jentsch, Bret A Morrow, D Eugene Redmond Jr and Robert H Roth. Clozapine Normalizes Prefrontal Cortex Dopamine Transmission in Monkeys Subchronically Exposed to Phencyclidine Neuropsychopharmacology. 2008.
Let’s try to put Jentsch’s PCP injections into context and imagine the situation from the monkeys’ perspective.

First, PCP is almost never injected. It is almost always smoked – sprinkled on tobacco or marijuana, and only very occasionally, snorted like cocaine. But it is almost never injected.

Second, nearly everyone who uses PCP knows they’re using PCP.

Third, the commonly reported recreational dose of PCP is 0.01-0.02 mg/kg.

Jentsch is injecting 15 to 30 times (0.3 mg/kg) the normal recreational dose of PCP into animals, ripped from their families, trapped in cages and being manhandled, who then start having unending nightmarish hallucinations for reasons they can’t imagine. And this goes on for two weeks, prior to them being killed.
And here's a bit of something I wrote about London a few years earlier:
Before considering her work, consider this:
For example, since smokers extract about 1 mg of nicotine per cigarette, a 1 pack per day (20 cigarettes per day) smoker likely receives near 100 percent nicotine replacement using a 21-mg/day patch. However, this patch dose likely underdoses heavier smokers, and higher nicotine doses (44-mg/day) have been shown to provide better relief from withdrawal symptoms and to increase short-term efficacy.” Randolph C. Barrows, Jr., M.D. SMOKING CESSATION (Chapter 3)
And here's a description of some of what she's doing to monkeys:
Two gonadally intact adolescent (4–5 years old) male rhesus monkeys (Macacca mulatta, 8.9 and 7.7 kg) participated in the studies. Monkeys were housed individually in temperature- and humidity-controlled rooms maintained on a 12 h light/dark schedule with lights on at 7:00 A.M. Monkeys were fed Monkey Diet Biscuit daily after each experimental session and were weighed biweekly. They participated in a psychological enrichment program. The animal protocol was approved by the Yale and Veterans Administration Animal Care and Use Committees and is in compliance with United States Public Health Service Policy on Humane Care and Use of Laboratory Animals

Nicotine was administered orally using the dose escalation paradigm described previously (Pietila et al., 1998 ). Nicotine (Sigma, St. Louis, MO) was administered in a saccharin–Kool-Aid (Kraft Foods, Northfield, IL) solution as the sole source of fluid on a daily basis (with the exception of days of nicotine withdrawal before each scan and also for the day of and immediately after the scan). During weeks 0–4, the animals increased their average nicotine consumption from 3.3 to 37.5 mg/kg. During the last 5–8 weeks of the study, the animals' average daily nicotine consumption was 30–38 mg/kg. After 6 and 8 weeks, the nicotine solution was removed and the monkeys had access to water.” Edythe D. London et al. Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers. J Neurosci. 2006.
So, during the final 3 weeks of the study, the larger of the two monkeys was being administered the equivalent of more than 13 packs a day (8.9 kg X 30--38 mg = 267 mgs) to almost 17 packs of cigarettes a day (8.9 kg X 38 mg = 338.2 mg).

The smaller monkey was being administered the equivalent of between about 11 packs a day and 14 packs a day.

“Such tactics are beyond contemptible, have no place in a civilized society …” says UCLA Chancellor Gene Block. Of course, Block is talking about flooding her mansion, not forcing the monkeys to drink nicotine-laden Kool-Aid.

People of Jentsch and London's evil ilk simply can't be trusted around animals. It's like letting serial sexual offenders run after-school programs for grade school kids.

No comments: