The theme of the meeting was “Promoting Innovation in PsychoNeuroImmunology: From Cytokines to Society.” The meeting was hosted by primate vivisector Chris Coe, director of the infamous and still controversial Harlow Primate Psychology Lab.
The Thursday afternoon schedule looked like this:
11:00 - 12:00 2008 NORMAN COUSINS MEMORIAL LECTURE:One of Andrew Miller’s papers is worth noting for its apparent needlessness, redundancy, and for the suffering the authors found so interesting: Felger JC, Alagbe O, Hu F, Mook D, Freeman AA, Sanchez MM, Kalin NH [Ned Kalin, a frequent collaborator of Richard Davidson's] Ratti E, Nemeroff CB, Miller AH. Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression. Biol Psychiatry. 2007.
Cytokines sing the blues: PNI at the translational interface
Dr. Andrew Miller, Emory University
12:00 - 1:30 LUNCH BREAK: Roundtable Discussion of NIH Funding Opportunities
1:30 - 3:30 PRESIDENTIAL SYMPOSIUM: Neural Mediation of the Effects of Stress and Psychological Factors on the Endocrine and Immune Systems
Dr. Richard Davidson Keynote Speaker Interactions between the brain and the periphery in the regulation and dysregulation of emotion, Univ. of Wisconsin, Madison, WI
The point of the study was to find out whether chronic administration of interferon-alpha caused depression, as it was already known to do to mice, since at least 2000 [Yamano M, Yuki H, Yasuda S, Miyata K. Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice.J Pharmacol Exp Ther. 2000], to rats, since at least 2001 [Sammut S, Goodall G, Muscat R.Acute interferon-alpha administration modulates sucrose consumption in the rat. Psychoneuroendocrinology. 2001], and to humans, since at least 1984 [Adams F, Quesada JR, Gutterman JU. Neuropsychiatric manifestations of human leukocyte interferon therapy in patients with cancer. JAMA. 1984.]
You can almost feel the authors’ giddy excitement at the discovery that, like mice, rats, and humans, rhesus monkeys also become depressed upon chronic administration of interferon-alpha:
Interestingly, 3 monkeys (two dominant and one subordinate) displayed depressive-like huddling behavior during IFN-alpha administration that was not affected by time. Post-hoc tests indicated that huddling behavior was significantly increased in relevant animals across all 4 weeks of IFN-alpha administration.As Miller finished up his lecture and the NIH Funding Opportunities Round Table was just getting underway, a few of the attendees wandered over to look out over beautiful Lake Monona and forget for just a moment the ugly reality of their or their colleagues’ chosen careers and the horror of the animals’ lives and pains being detailed in the graphs and posters at the convention. But, alas, the calming view was marred by the presence of terrorists and a possible aquatic assault...
Clandestine reports from within the conference center informed the activists that the little ship had disturbed the assurance of the conference attendees and that they were trying mightily to ignore the disruption, but like moths to a flame they came skulking over one or two at a time, sometimes in threes and fours to steal glances at actual public opinion of animal experimentation and vivisectors.
As the boat sailed away, it was time for Richie Davidson to begin his keynote address, paying lip service, no doubt, to his kindness—honed by his years of “compassion meditation”—and his personal relationship with the Dalai Lama.