If like me, you have noticed the cult-like quasi-religious overtones of the vivisection industry, you might find The Authoritarians, by University of Manitoba Associate Professor Bob Altemeyer, of interest.
If you have merely scratched your head wondering how Bush and company came to power and why they have done the things they have, then you'll find this a facinating examination of our darker side.
Tuesday, February 27, 2007
Thursday, February 15, 2007
On the Endangered Lab Chimp
The January 26, 2007 issue of Science includes an article written by Jon Cohen titled “The Endangered Lab Chimp.” [Vol. 315. no. 5811, pp. 450 – 452.]
Mr. Cohen’s article begins with the headline: “A decline in the number of chimpanzees available for biomedical research in the U.S. has sparked a growing debate on the opportunities and costs of studies with our closest relatives.”
I don’t know whether these are Cohen’s words or an editor’s, but they are indicative of the ivory tower or head-in-the-sand mentality so often expressed in Science and similar journals. Who could be so out of touch as to claim that the debate over our use of chimpanzees is a new phenomenon sparked by the decline in their availability? Have Cohen and the editors of Science never heard of Jane Goodall?
Before bloodying my hands with a dissection of Cohen’s article, let me first say a bit about the author and the journal’s decision to have Cohen write about this issue. Cohen is the author of Shots in the Dark: The Wayward Search for an AIDS Vaccine (W. W. Norton & Company; December 2001.)
Cohen believes that the way to an HIV vaccine is a “March of Dollars,” a modern day March of Dimes, that he calls a “grand experiment” that would “possibly use more moneys than are currently available for research.” (p 329.) In the chapter notes he clarifies his estimate to a mere 1000 monkeys. Cohen seems unmoved by the fact that using monkeys in AIDS research has resulted in dozens of vaccines – all successful in monkeys, all failures in humans. Cohen has a hard time understanding that HIV is uniquely a human disease.
In Shots, Cohen urges us to keep doing something that has proven ineffective, like sending more troops to Iraq.
Who better to write about the use of chimpanzees in biomedical research and the debate that’s just been sparked by “a decline in the number of chimpanzees available for biomedical research”?
Cohen begins his article by twisting the facts into a scenario that he presumably finds worrying and apparently hopes will worry the biomedical community as well. He writes:
Cohen writes: “The push to breed more chimpanzees is forcing a reexamination of questions that have long surrounded research with our closest relatives, an endangered species that is rapidly disappearing in the wild.”
Given the fact that so few chimpanzees are being used in so few studies, just what push is Cohen referring to? Most of the 1100 chimpanzees being held at federally funded laboratories are being warehoused. The lack of demand for chimpanzees is exactly what led to the NIH supporting the passage of the Chimpanzees Health Improvement, Maintenance, and Protection (CHIMP) Act of December 2000.
Cohen:
Chimpanzees, the animal model with the most direct relevance to AIDS in humans, according to Letvin, have been abandoned as HIV models. How could Letvin’s opinion on this issue have any weight whatsoever? His claim that this animal model has led to “enormously valuable” medical advances in the past is just more hyperbole. The single medical advance that could conceivably be attributed to some use of chimpanzees is the development of the hepatitis B vaccine, but even this claim has been challenged.
Undoubtedly, Cohen went to Letvin for a statement because Letvin has built his career on plowing ahead with ever more NIH-funded SIV experiments on monkeys, Cohen’s version of the AIDS Grail.
Cohen seems to almost understand that biomedical research with chimpanzees has been a bust:
Cohen finally gets to his claim about what "sparked" the "recent debate."
Not surprisingly, the commentary was written by John VandeBerg, director of Southwest National Primate Research Center, and Stuart Zola, director of Yerkes National Primate Research Center, which just happen to be the only two of the eight National Primate Research Centers that have chimpanzees. To Southwest and Yerkes, these animals are not chimpanzees, they are cash cows.
Co-authors included Jo Fritz, Primate Foundation of Arizona, Mesa; D. Rick Lee, Alamogordo Primate Facility, New Mexico; Thomas J. Rowell, University of Louisiana at Lafayette, Louisiana; and William C. Satterfield, M. D. Anderson Cancer Center, Bastrop, Texas. These are the only facilities in the U.S. holding chimpanzees for research.
I wonder what the buggy whip manufactures had to say about the importance of buggy whips as their industry failed?
From Table 1: Five-year projection of the number of chimpanzees available for research in the absence of breeding. (VandeBerg JL, Zola SM. A unique biomedical resource at risk. Nature. 2005 Sep 1.)
Cohen claims that VandeBerg report at a “chimp meeting” that current trends suggest that the US chimpanzee population will be too old to breed in a few years “startled many at the meeting…. Others noted that the aging of the population is already limiting brain and behavioral research that depends on younger animals.”
Given the tiny number of studies recently published or underway using chimpanzees in brain and behavioral research, this claim should be understood to be hyperbole as well. It also begs the question as to whether any of these very few studies have any merit in the first place.
Cohen goes on to cite other nations and private institutions that have halted their use of chimpanzees. He quotes a few scientists who argue from an ethical perspective that chimpanzees should no longer be used in research.
To counter this nod to apparent balance, Cohen again relies on vested parties:
And of course, Cohen gives the last word to Letvin:
Mr. Cohen’s article begins with the headline: “A decline in the number of chimpanzees available for biomedical research in the U.S. has sparked a growing debate on the opportunities and costs of studies with our closest relatives.”
I don’t know whether these are Cohen’s words or an editor’s, but they are indicative of the ivory tower or head-in-the-sand mentality so often expressed in Science and similar journals. Who could be so out of touch as to claim that the debate over our use of chimpanzees is a new phenomenon sparked by the decline in their availability? Have Cohen and the editors of Science never heard of Jane Goodall?
Before bloodying my hands with a dissection of Cohen’s article, let me first say a bit about the author and the journal’s decision to have Cohen write about this issue. Cohen is the author of Shots in the Dark: The Wayward Search for an AIDS Vaccine (W. W. Norton & Company; December 2001.)
Cohen believes that the way to an HIV vaccine is a “March of Dollars,” a modern day March of Dimes, that he calls a “grand experiment” that would “possibly use more moneys than are currently available for research.” (p 329.) In the chapter notes he clarifies his estimate to a mere 1000 monkeys. Cohen seems unmoved by the fact that using monkeys in AIDS research has resulted in dozens of vaccines – all successful in monkeys, all failures in humans. Cohen has a hard time understanding that HIV is uniquely a human disease.
In Shots, Cohen urges us to keep doing something that has proven ineffective, like sending more troops to Iraq.
Who better to write about the use of chimpanzees in biomedical research and the debate that’s just been sparked by “a decline in the number of chimpanzees available for biomedical research”?
Cohen begins his article by twisting the facts into a scenario that he presumably finds worrying and apparently hopes will worry the biomedical community as well. He writes:
As a result, [of the 2000 CHiMP Act, and animals being moved into a quasi-sanctuary] the population has dropped from 1500 in 1996 to 1133 in October 2006. Now, many researchers who conduct biomedical research on chimpanzees are worried that the number of breeding animals is declining so rapidly that there will soon not be enough left to sustain the population. “The population is heading for a cliff,” says Todd Preuss, a neuroscientist at Yerkes National Primate Research Center in Atlanta, Georgia, which has the country’s oldest colony of research chimpanzees. “If we don’t start breeding these chimpanzees soon, they’re going to go away, and they’re going to be gone for good.”First, there aren’t “many researchers who conduct biomedical research on chimpanzees.” In fact, in 2004, there were a total of 25 principal investigators (the scientist whose name is on the grant) using chimpanzees. About the only biomedical research niche found for chimpanzees is in hepatitis research. In 2004, there were 21 funded studies underway by 17 principal investigators studying hepatitis. Most of these studies were on-going and using the same chimpanzees year after year. Chimpanzees can remain in a hepatitis protocol for many years and be subjected to many painful and debilitating liver biopsies. In 2004, there were over 1000 studies underway using monkeys, and many thousands of studies using mice. Cohen’s claim is hyperbole.
Cohen writes: “The push to breed more chimpanzees is forcing a reexamination of questions that have long surrounded research with our closest relatives, an endangered species that is rapidly disappearing in the wild.”
Given the fact that so few chimpanzees are being used in so few studies, just what push is Cohen referring to? Most of the 1100 chimpanzees being held at federally funded laboratories are being warehoused. The lack of demand for chimpanzees is exactly what led to the NIH supporting the passage of the Chimpanzees Health Improvement, Maintenance, and Protection (CHIMP) Act of December 2000.
Cohen:
Still other researchers caution against making a blanket proclamation that invasive experiments with chimpanzees are unethical. “To draw a hypothetical line in the air I don’t think does justice to the subtlety of these questions,” says Norman Letvin, an immunologist at the Beth Israel Deaconess Medical Center in Boston, who has done AIDS vaccine experiments in chimpanzees and monkeys. “These kinds of discussions need to be focused on very specific questions about a particular study.” Letvin no longer experiments on chimps and says he can’t see any compelling reason today to use large numbers of them for biomedical research. But he stresses, as do many other investigators, that this animal model has led to “enormously valuable” medical advances in the past and may well in the future.Letvin’s research and his judgment are proven failures. In 1987 he declared:
Substantial advances have already been made in the understanding of acquired immunodeficiency syndrome (AIDS). The major issues for AIDS research during the next few years must be practical ones: the development of a safe, effective vaccine for individuals not yet infected with the causative virus and the development of drug therapies for those already infected. Suitable animal models will be needed for studies designed to achieve these goals. Areas of investigation in animal models can be divided into four categories on the basis of increasing direct relevance to AIDS in humans: retroviruses that have no obvious, close relation to human immunodeficiency virus (HIV) but can induce chronic diseases with manifestations that include immunologic abnormalities; ungulate lentiviruses; HIV-related viruses of Old World primates; and HIV infection of chimpanzees. It is hoped that important research developments in experimental models can be quickly extrapolated to human AIDS. Desrosiers RC, Letvin NL. Animal models for acquired immunodeficiency syndrome. Rev Infect Dis. 1987 May-Jun;9(3):438-46. Review.(Ron Desrosiers, Director of the New England National Primate Research Center may hold the record for announcements that he has found a vaccine for HIV.)
Chimpanzees, the animal model with the most direct relevance to AIDS in humans, according to Letvin, have been abandoned as HIV models. How could Letvin’s opinion on this issue have any weight whatsoever? His claim that this animal model has led to “enormously valuable” medical advances in the past is just more hyperbole. The single medical advance that could conceivably be attributed to some use of chimpanzees is the development of the hepatitis B vaccine, but even this claim has been challenged.
Undoubtedly, Cohen went to Letvin for a statement because Letvin has built his career on plowing ahead with ever more NIH-funded SIV experiments on monkeys, Cohen’s version of the AIDS Grail.
Cohen seems to almost understand that biomedical research with chimpanzees has been a bust:
As many proponents of this animal model note, such research played a crucial role in the development of the vaccine for hepatitis B, a sometimes lethal virus that has infected 2 billion people. But scientists around the world have also performed studies that are now considered bizarre or brutal. The U.S. Air Force’s chimponaut program shot them into space. Other researchers harvested their organs for human transplants, implanted electrodes into their brains to study sleep, and used them to gauge the effects of alcohol and marijuana. And a Soviet scientist attempted to inseminate them with human sperm to make a “humanzee.”He follows up by noting that: “the chimpanzee AIDS model had problems from the get-go.”
Cohen finally gets to his claim about what "sparked" the "recent debate."
With the publication of the first draft of the chimpanzee genome in September 2005, calls mounted for NCRR to lift the moratorium. In a commentary in that same issue of Nature, the heads of the U.S. primate centers again extolled the benefits of maintaining this “unique resource” and warned that if the moratorium were not lifted, the population would sharply decline within 5 years.Cohen spins the facts. The commentary he refers to in Nature was not written by “the heads of the U.S. primate centers.” (VandeBerg JL, Zola SM. A unique biomedical resource at risk. Nature. 2005 Sep 1.) The term “U.S. primate centers” is invariably used to refer to the eight NIH National Primate Research Centers.
Since then, one of the co-authors, John VandeBerg, director of Southwest National Primate Research Center, has performed a more detailed analysis of the age and health status of the chimps housed at all six facilities. At a chimp meeting at Yerkes in October 2006, Vande-Berg said that of the 1133 animals then available, just 200 females were potential breeders. If the breeding moratorium were not lifted, he added, there will be no research chimps left by 2037 when all of these chimpanzees will have died.
Not surprisingly, the commentary was written by John VandeBerg, director of Southwest National Primate Research Center, and Stuart Zola, director of Yerkes National Primate Research Center, which just happen to be the only two of the eight National Primate Research Centers that have chimpanzees. To Southwest and Yerkes, these animals are not chimpanzees, they are cash cows.
Co-authors included Jo Fritz, Primate Foundation of Arizona, Mesa; D. Rick Lee, Alamogordo Primate Facility, New Mexico; Thomas J. Rowell, University of Louisiana at Lafayette, Louisiana; and William C. Satterfield, M. D. Anderson Cancer Center, Bastrop, Texas. These are the only facilities in the U.S. holding chimpanzees for research.
I wonder what the buggy whip manufactures had to say about the importance of buggy whips as their industry failed?
From Table 1: Five-year projection of the number of chimpanzees available for research in the absence of breeding. (VandeBerg JL, Zola SM. A unique biomedical resource at risk. Nature. 2005 Sep 1.)Cohen claims that VandeBerg report at a “chimp meeting” that current trends suggest that the US chimpanzee population will be too old to breed in a few years “startled many at the meeting…. Others noted that the aging of the population is already limiting brain and behavioral research that depends on younger animals.”
Given the tiny number of studies recently published or underway using chimpanzees in brain and behavioral research, this claim should be understood to be hyperbole as well. It also begs the question as to whether any of these very few studies have any merit in the first place.
Cohen goes on to cite other nations and private institutions that have halted their use of chimpanzees. He quotes a few scientists who argue from an ethical perspective that chimpanzees should no longer be used in research.
To counter this nod to apparent balance, Cohen again relies on vested parties:
In their 2005 Nature commentary, VandeBerg and co-authors argued that chimpanzees should remain available for disease research and for testing drugs and vaccines. VandeBerg notes that some proprietary experiments with monoclonal antibodies done for commercial companies have led to illness or even death of chimps—preventing harmful drugs from entering human trials. “It’s unethical from a human standpoint to not do this research,” he says.This is a pretty clear example of the spin and fear mongering used by primate vivisectors everywhere. There is no reason to assume that a drug or disease that negatively affects a chimpanzee will have a similar effect in a human or visa versa. The most glaring and ironic example given Cohen’s biases is HIV: deadly in humans, a brief sniffle in chimpanzees. VandeBerg has a weak grasp on ethics.
And of course, Cohen gives the last word to Letvin:
… others say the U.S. government should simply support a core breeding group of chimpanzees for biomedical research as an insurance policy for future emergencies. Beth Israel’s Letvin agrees with this minimalist strategy. “If we’ve learned anything over the years, it’s that we don’t know what the next epidemic will be and what the next major health crisis is going to be,” says Letvin. “It would be foolhardy to take any potential animal model off the table.”Letvin’s predictions and research have so far missed the target altogether. Cohen cheers him on.
Friday, February 9, 2007
Saturday, February 3, 2007
The Poisoned Plum
A January 31, 2007 press release from the University of Wisconsin, Madison announced that Thomas McKenna, director of the Foreign Animal Disease Diagnostic Laboratory at Plum Island, N.Y., where he has worked since 1995, has been chosen to head the Wisconsin Veterinary Diagnostic Laboratory which includes a self-contained Biological Safety Level 3 laboratory, where work with highly infectious organisms and other potential bioterrorism agents will be performed.
The release, disseminated as original writing in a local newspaper, quoted Daryl Buss, dean of the School of Veterinary Medicine: “We are highly impressed with Tom's leadership skills, his scientific credentials and his ability to manage a resource that is vitally important to Wisconsin citizens.”
I attended a presentation by dean Buss and others at the November 30, 2006, Town of Dunn town hall meeting. A select group of purported university experts went to Dunn to explain why the University had offered a 160 acre parcel of land it owns in the township to the U.S. Department of Homeland Security as a site for a new Biological Safety Level 4 laboratory.
A Biological Safety Level 4 (BSL-4) laboratory studies the most deadly, most contagious diseases known. The new lab, wherever it is finally built, will be called the National Bio and Agro Defense Facility (NABF).
During the Dunn town hall meeting, dean Buss explained that the new facility would be a replacement for U.S. government owned Plum Island. He explained that Plum Island was an exemplary laboratory, but that it was deemed too old to fully renovate, so Homeland Security was trying to find a location to build a new laboratory.
During the Q&A, an elderly woman stood and asked the panel of university experts whether any of them had read the book she was holding, Lab 257. The experts looked around at each other, no, none of them was familiar with the book. Mario Cuomo, former governor of New York, may have been prescient when he worried that if someone didn’t force the government to do something about Plum Island, that the author’s “brilliant work will have been wasted and we may be the victims, once again, of government inadvertence.”
There is something contradictory in dean Buss’s praise for Thomas McKenna’s leadership during his twelve years at Plum Island and the problems at Plum Island revealed by Michael C. Carroll’s Lab 257: The Disturbing Story of the Government’s Secret Plum Island Germ Laboratory.
There is something disturbing about dean Buss claiming that McKenna is impressive without, apparently, having familiarized himself with well researched criticisms of Plum Island’s history of germ research.
There is something nefarious in the fact that the university is trying to convince the Town of Dunn that it has nothing to worry about if Homeland Security builds a BSL-4 lab replacement for Plum Island in its back yard. Now, another expert will be able to say that he worked at Plum Island and the people of Dunn and nearby Madison should feel perfectly safe.
Understandably, getting information from Plum Island has proven to be as difficult as getting information from the UW. What has emerged from a large body of evidence, circumstantial and factual, is the likelihood that Plum Island is responsible for a number of disease outbreaks that have proven to be national public health and agricultural nightmares.
There is compelling evidence that Plum Island is responsible for the introduction into the United States of Lyme Disease, West Nile virus, Dutch duck plague, and the reintroduction hoof-and-mouth disease. Plum Island’s biocontainment mechanisms were allowed to deteriorate and remained non-functional for many years. Security was lax. Accidents were common. Plum Island’s apparent catastrophic failure to protect the public must be borne in part by Thomas McKenna.
Naming McKenna to lead a BSL-3 laboratory and likely become an advocate for the proposed BSL-4 laboratory – without fully understanding the history of Plum Island – is yet another violation of the public’s trust by the University of Wisconsin.
The release, disseminated as original writing in a local newspaper, quoted Daryl Buss, dean of the School of Veterinary Medicine: “We are highly impressed with Tom's leadership skills, his scientific credentials and his ability to manage a resource that is vitally important to Wisconsin citizens.”
I attended a presentation by dean Buss and others at the November 30, 2006, Town of Dunn town hall meeting. A select group of purported university experts went to Dunn to explain why the University had offered a 160 acre parcel of land it owns in the township to the U.S. Department of Homeland Security as a site for a new Biological Safety Level 4 laboratory.
A Biological Safety Level 4 (BSL-4) laboratory studies the most deadly, most contagious diseases known. The new lab, wherever it is finally built, will be called the National Bio and Agro Defense Facility (NABF).
During the Dunn town hall meeting, dean Buss explained that the new facility would be a replacement for U.S. government owned Plum Island. He explained that Plum Island was an exemplary laboratory, but that it was deemed too old to fully renovate, so Homeland Security was trying to find a location to build a new laboratory.
During the Q&A, an elderly woman stood and asked the panel of university experts whether any of them had read the book she was holding, Lab 257. The experts looked around at each other, no, none of them was familiar with the book. Mario Cuomo, former governor of New York, may have been prescient when he worried that if someone didn’t force the government to do something about Plum Island, that the author’s “brilliant work will have been wasted and we may be the victims, once again, of government inadvertence.”
There is something contradictory in dean Buss’s praise for Thomas McKenna’s leadership during his twelve years at Plum Island and the problems at Plum Island revealed by Michael C. Carroll’s Lab 257: The Disturbing Story of the Government’s Secret Plum Island Germ Laboratory.
There is something disturbing about dean Buss claiming that McKenna is impressive without, apparently, having familiarized himself with well researched criticisms of Plum Island’s history of germ research.
There is something nefarious in the fact that the university is trying to convince the Town of Dunn that it has nothing to worry about if Homeland Security builds a BSL-4 lab replacement for Plum Island in its back yard. Now, another expert will be able to say that he worked at Plum Island and the people of Dunn and nearby Madison should feel perfectly safe.
Understandably, getting information from Plum Island has proven to be as difficult as getting information from the UW. What has emerged from a large body of evidence, circumstantial and factual, is the likelihood that Plum Island is responsible for a number of disease outbreaks that have proven to be national public health and agricultural nightmares.
There is compelling evidence that Plum Island is responsible for the introduction into the United States of Lyme Disease, West Nile virus, Dutch duck plague, and the reintroduction hoof-and-mouth disease. Plum Island’s biocontainment mechanisms were allowed to deteriorate and remained non-functional for many years. Security was lax. Accidents were common. Plum Island’s apparent catastrophic failure to protect the public must be borne in part by Thomas McKenna.
Naming McKenna to lead a BSL-3 laboratory and likely become an advocate for the proposed BSL-4 laboratory – without fully understanding the history of Plum Island – is yet another violation of the public’s trust by the University of Wisconsin.
Friday, February 2, 2007
Hook, Line, and Sinker
“I don't believe that nicotine or our products are addictive.” U.S. Tobacco Company CEO Joseph Taddeo. 1994 Congressional Testimony.Why are so many people so absolutely gullible? Why do so many people trust government and industry spokespersons? Why do so many people think Rush Limbaugh or a priest, a public relations spokesperson, or someone financially vested in whatever they might be peddling can be trusted? What makes us, generally, so stupid?
“If some environmentalists are to be believed, we are on the verge of massive global climate change…” http://www.skepticism.net/Part of the answer must lie in the fact that many of us are willing to lie, to deceive, are greedy, and simply hate anyone who isn’t also greedier than hell.
“In fact, trans fats have been a part of the American diet since the early 1900s and they are hardly toxic.” http://www.consumerfreedom.com/Part of the answer must lie in the fact that the intelligence of society’s members falls out along a bell-shaped curve. The median IQ is about 100. That’s not real smart. Many more than half of us are pretty dumb. Real dumb.
“When you track the genealogical record in God's Word you will discover that the earth is just over 6,000 years old.” http://www.godsaidmansaid.com/home.aspAdd greed into this mix and you find lots of self-serving predators and their hirelings willing to sell you a medicine they know is going to do nothing or even hurt your child, hide the fact their products are poisoning the earth, or the fact that they get their money directly from your paycheck and contribute nothing but sorrow and suffering.
“Animal research has played a vital role in virtually every major medical advance of the last century.” Foundation For Biomedical Research.It’s pretty sad. In the past, this recognition has led to revolution. Unfortunately, during a revolution dummies get used and different liars take control.
“One of the main goals of laboratory animal scientists is assuring research animals are not exposed to any unnecessary pain or stress.” Kids 4 Research. http://www.kids4research.org/animals.htmlThe way out of this morass is probably a governmental system based on proportional representation. With our current winner-takes-all system, money can be concentrated on key races and assure that the powerful stay in control.
“Nuclear energy has perhaps the lowest impact on the environment—including air, land, water, and wildlife—of any energy source, because it does not emit harmful gases, isolates its waste from the environment, and requires less area to produce the same amount of electricity as other sources.” The Nuclear Energy Institute.America is capitalism run amok.
“These results show that HIV-1 can induce AIDS in chimpanzees and suggest that long-term passage of HIV-1 in chimpanzees can result in the development of a more pathogenic virus.”Virol., May 1997, 4086-4091, Vol 71, No. 5 Development of AIDS in a chimpanzee infected with human immunodeficiency virus type Francis Novembre, et al. Department of Pathology, Emory University, Atlanta, Georgia, USA. fnovembr@rmy.emory.edu
Hook, line, and sinker.
“Simply stated, there is no doubt that Saddam Hussein now has weapons of mass destruction.” Remarks by the Vice President to the Veterans of Foreign Wars 103rd National Convention. August 26, 2002.
Who gives a hoot about hungry kids?
Research results direct from the National Institutes of Health. Rather than a national healthcare system we support a white-coat welfare system.
Age-Dependent Variation in Behavior Following Acute Ethanol Administration in Male and Female Adolescent Rhesus Macaques(Macaca mulatta). Alcohol Clin Exp Res. 2007 Feb;31(2):228-37.
Schwandt ML, Barr CS, Suomi SJ [Harry Harlow's best-known grad student], Higley JD. Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, Poolesville, Maryland.
Background: There has been considerable focus on the adolescent stage of development in the study of alcohol use and the etiology of alcohol-related problems. Because adolescence is a process of dynamic change rather than a discrete or static stage of development, it is important to consider ontogenetic changes in the response to ethanol within the adolescent time period. In rodents, levels of ethanol-induced motor impairment have been shown to increase from early to late adolescence. This study investigated associations between behavior following acute ethanol administration and age, rearing condition (mother-reared vs nursery-reared), and serotonin transporter (rh5-HTTLPR) genotype in a sample of alcohol-naive adolescent rhesus macaques. Methods: Rhesus macaques (n=97; 41 males, 56 females), ranging in age from 28 to 48 months, were administered intravenous (IV) doses of ethanol (2.2 g/kg for males, 2.0 g/kg for females) twice in 2 separate testing sessions. A saline/ethanol group (n=16; 8 males, 6 females) was administered saline in 1 testing session and ethanol in the second session. Following each IV injection, subjects underwent a 30-minute general motor behavioral assessment. Behavior in the saline/ethanol group was compared between the saline and ethanol-testing sessions using analysis of variance. Behavioral data for the larger study sample were averaged between the 2 testing sessions and summarized using factor analysis. Rotated factor scores were used as dependent variables in multiple regression analyses to test for relationships between behavior and age, rearing condition, and rh5-HTTLPR genotype. Results: During the ethanol-testing session, behaviors indicative of motor impairment (stumbles, falls, sways, bumping the wall, and unsuccessful jumps) were frequently observed in the saline/ethanol group, while they did not occur under the saline-testing session. Factor analysis of behavior following ethanol administration in the larger study sample yielded 3 factors: Ataxia, Impaired Jumping Ability, and Stimulation. Significant negative correlations between age and Ataxia were found for both males and females. Females also exhibited positive correlations between age and Impaired Jumping Ability and age and Stimulation. No significant correlations were found with either rearing condition or rh5-HTTLPR genotype. Conclusions: These findings suggest that ontogenetic changes during adolescence in the behavioral response to ethanol differ between rodents and primates. Furthermore, sex differences in the behavioral response to ethanol appear to develop during adolescence.
"During the ethanol-testing session, behaviors indicative of motor impairment (stumbles, falls, sways, bumping the wall, and unsuccessful jumps) were frequently observed in the saline/ethanol group, while they did not occur under the saline-testing session."
Wow! That knowledge is much more important than making sure children get food and healthcare. I trust the govenment to always act in my best interest.
Age-Dependent Variation in Behavior Following Acute Ethanol Administration in Male and Female Adolescent Rhesus Macaques(Macaca mulatta). Alcohol Clin Exp Res. 2007 Feb;31(2):228-37.
Schwandt ML, Barr CS, Suomi SJ [Harry Harlow's best-known grad student], Higley JD. Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, Poolesville, Maryland.
Background: There has been considerable focus on the adolescent stage of development in the study of alcohol use and the etiology of alcohol-related problems. Because adolescence is a process of dynamic change rather than a discrete or static stage of development, it is important to consider ontogenetic changes in the response to ethanol within the adolescent time period. In rodents, levels of ethanol-induced motor impairment have been shown to increase from early to late adolescence. This study investigated associations between behavior following acute ethanol administration and age, rearing condition (mother-reared vs nursery-reared), and serotonin transporter (rh5-HTTLPR) genotype in a sample of alcohol-naive adolescent rhesus macaques. Methods: Rhesus macaques (n=97; 41 males, 56 females), ranging in age from 28 to 48 months, were administered intravenous (IV) doses of ethanol (2.2 g/kg for males, 2.0 g/kg for females) twice in 2 separate testing sessions. A saline/ethanol group (n=16; 8 males, 6 females) was administered saline in 1 testing session and ethanol in the second session. Following each IV injection, subjects underwent a 30-minute general motor behavioral assessment. Behavior in the saline/ethanol group was compared between the saline and ethanol-testing sessions using analysis of variance. Behavioral data for the larger study sample were averaged between the 2 testing sessions and summarized using factor analysis. Rotated factor scores were used as dependent variables in multiple regression analyses to test for relationships between behavior and age, rearing condition, and rh5-HTTLPR genotype. Results: During the ethanol-testing session, behaviors indicative of motor impairment (stumbles, falls, sways, bumping the wall, and unsuccessful jumps) were frequently observed in the saline/ethanol group, while they did not occur under the saline-testing session. Factor analysis of behavior following ethanol administration in the larger study sample yielded 3 factors: Ataxia, Impaired Jumping Ability, and Stimulation. Significant negative correlations between age and Ataxia were found for both males and females. Females also exhibited positive correlations between age and Impaired Jumping Ability and age and Stimulation. No significant correlations were found with either rearing condition or rh5-HTTLPR genotype. Conclusions: These findings suggest that ontogenetic changes during adolescence in the behavioral response to ethanol differ between rodents and primates. Furthermore, sex differences in the behavioral response to ethanol appear to develop during adolescence.
"During the ethanol-testing session, behaviors indicative of motor impairment (stumbles, falls, sways, bumping the wall, and unsuccessful jumps) were frequently observed in the saline/ethanol group, while they did not occur under the saline-testing session."
Wow! That knowledge is much more important than making sure children get food and healthcare. I trust the govenment to always act in my best interest.
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