“NIH-funded mouse study sheds light on neural risks associated with prenatal alcohol exposure.”
“The team administered alcohol to pregnant mice at levels that resulted in peak blood alcohol concentrations approximately like those of people who either drink socially or who have severe alcohol use disorder. They then examined fetal brain cell response to alcohol and two other environmental stressors --hydrogen peroxide and methyl mercury—all known to induce oxidative stress...”.
PI/Project Leader: HASHIMOTO-TORII, KAZUE
ROLES OF PRIMARY CILIA IN THE DEVELOPING CORTEX EXPOSED TO ALCOHOL
Project Number: 1R21AA024882-01A1
Total Funding: $207,813.
Direct Costs: $118,750. Indirect Costs: $89,063
THE ROLES OF ALCOHOL-INDUCIBLE RNA-OPERONS IN THE FETAL BRAIN
Project Number: 1R01AA025215-01
Total Funding: $368,513.
Direct Costs: $210,579. Indirect Costs: $157,934
BIOMARKER FOR INTELLECTUAL DISABILITY IN CHILDREN PRENATALLY EXPOSED TO ALCOHOL [“The Hashimoto-Torii lab will perform the single-cell droplet digital PCR- based biomarker analyses (drop-PCR) with both human and mouse blood samples. The Torii lab will collect the mouse blood samples, perform comprehensive mouse behavior analyses, and statistically evaluate potential correlations between the animal behaviors and drop-PCR results.”] Project Number: 1UH2AA026106-01 Total Funding: $261,791.
Direct Costs: $157,340. Indirect Costs: $104,451
Meanwhile,
In 2007, it was reported that women who received 10- to 15-minutes of counseling from a nutritionist about the risks of drinking were 5 times more likely to report abstinence during their pregnancy. [O’Connor, Mary J., and Shannon E. Whaley. "Brief intervention for alcohol use by pregnant women." American journal of public health 97.2 (2007): 252-258.]
