UW-Madison's
PHS self-reports
9A to 9Z
9A
2/25/2019
"... OLAW understands that a nonhuman primate received two challenges with
simian immunodeficiency virus, though the protocol was approved for only one. No
adverse effects were reported for the animal."[!]
"... OLAW understands that measures have been implemented to prevent recurrence
of this problem."
9B
7/9/2019
"... OLAW understands that in late November 2018 while laboratory personnel were
separating mice into new caging in a core facility [School of Medicine], they
failed to remove a sticker that covered the outlet on one water bottle. The
animals in that cage did not have access to water and two died mice died."
"... actions taken to resolve the issues and prevent recurrence were
appropriate."
9C
4/23/19
"... OLAW understands that a monkey cage door had not been appropriately locked
by staff and two animals escaped into the room. They fought with other monkeys
in the room and one sustained a finger injury and one sustained a tongue injury.
Another caged monkeys also sustained a tongue injury."
"... OLAW understands that measures have been implemented to correct and reduce
the likelihood of a recurrence of this problem."
9D
4/23/2019
"... OLAW understands that due to misidentification of the tattoos, one of two
paired of cynomolgus monkeys was subjected to unnecessary anesthesia and
analgesia.
"... OLAW understands that measures have been implemented to prevent recurrence
of this problem."
9E
4/9/2019
"... OLAW understands that two mouse pups in separate cages were found trapped
between the wire lid and cage top. The mice had no access to water and one died.
This incident occurred following weaning of the mice by laboratory staff."
"... OLAW understands that measures have been implemented to correct and prevent
recurrence of this problem."
9F
6/17/2019
"... OLAW understands that six live neonatal mice were found in the carcass
freezer due to a failure to ensure death after asphyxiation with CO2 for
euthanasia. The required secondary physical method had not been used.
"... OLAW understands that measures have been implemented to correct and prevent
recurrence of this problem."
9G
7/22/2019
"... OLAW understands that a marmoset sustained a broken femur during approved
protocol manipulations."
"...OLAW understands that measures have been implemented to address this adverse
event."
This event led to the the university being cited for a
Critical violation of the Animal Welfare Act
on 7/9 by USDA/APHIS. The marmoset seems to have struggle so intensely when
being restrained while was being done to them that they broke their leg. The leg
was injured to such a degree that it was amputated.
9H
6/17/2019
"... OLAW understands that following an approved eye procedure in a rabbit, no
documentation was made regarding postprocedural monitoring or administration of
analgesia."
"... OLAW understands that measures have been implemented to correct and prevent
recurrence of this problem."
9I
6/17/2019
"... OLAW understands that 18 mice had escaped their cages by chewing through
the hole for the water bottle. A research technician had removed the bottles to
replace them but was gone for several hours.
The corrective action consisted of catching 16 mice and placing them in a clean
cage or euthanizing them. Two mice were not captured."
"... OLAW understands that measures have been implemented to correct and prevent
recurrence of this problem."
9J
Duplicate/"does not exist" per DHHS
9K
7/8/2019
"... OLAW understands that a veterinary technician observed a wound in an adult
macaque and inadvertently documented this finding and treatment plan in the
enclosure mate's medical record. As a result the wrong macaque received
anti-inflamatory medication for two days which delayed treatment for the injured
animal until the error was discovered. "
"... OLAW concurs with the actions taken by the institution and the IACUC to
adhere to the PHS policy."
9L
7/8/2019
"... OLAW understands that an animal caretaker failed to properly lock an animal
enclosure and a student animal caretaker responsible for checking the enclosure
failed to identify the improperly attached lock. Three macaques sustained
injuries that required veterinary intervention after two adult macaques exited
their primary enclosure and after one of the two interacted with an animal still
in his/her enclosure.
"... OLAW concurs with the actions taken by the institution and the IACUC to
adhere to the PHS policy."
9M
7/17/2019
"... OLAW understands that five infant rhesus monkeys were subjected to
behavioral tests at a different frequency than described in the approved
protocol. The tests involved removing the infants from their mothers for one
hour and conducting the testing. Conducting the tests three in a row rather than
once per month resulted in better outcomes.
"The corrective action consisted in amending the protocol to reflect the actual
testing schedule."
"... OLAW understands that measures have been implemented to correct and prevent
recurrence of this problem."
Note: The correspondence in the case file describes a second violation left
unremarked on by OLAW. The university reported: "... a veterinary technician
inadvertently administered an incorrect dose of an anti-inflammatory (meloxicam)
to an infant rhesus macaque after identification tattoos were place on its
ears."
9N
7/17/2019
"... OLAW understands that a greater than approved dose of an anti-inflamatory
agent was inadvertently given to an infant macaque.
"... OLAW understands that measures have been implemented to correct and prevent
recurrence of this problem."
9O
12/10/2019
"... This Office understands that the SMPH IACUC determined that instances of
noncompliance occurred with respect to: researchers use of expired buprenorphine
on a group of mice during protocol-approved procedure.
"... OLAW understands that the University of Wisconsin-Madison has implemented
appropriate measures to correct and prevent recurrences of this problem and is
now compliant with provisions of the PHS Policy."
9P
10/28/2019
"... OLAW understands that in late August, 2019, an adult marmoset received an
overdose of an anti-inflammatory agent due to an error by a veterinary
technician."
"The prompt consideration of this matter by the University of Wisconsin -
Madison was consistent with the philosophy of institutional self-regulation.
Similarly, the actions taken to resolve the issue and prevent recurrence were
appropriate."
9Q
10/28/2019
"... OLAW understands that on September 19, 2019, an adult rhesus monkey was
injured in its cage by another rhesus that had escaped its enclosure. An animal
caretaker had not placed a lock on one of the doors of the enclosure. The
injuries required veterinary attention."
"The prompt consideration of this matter by the University of Wisconsin -
Madison was consistent with the philosophy of institutional self-regulation.
Similarly, the actions taken to resolve the issue and prevent recurrence were
appropriate."
9R
10/28/2019
"... OLAW understands that on August 28,two macaques sustained injuries that
required veterinary attention after they removed the divider separating their
home enclosures. The incident occurred after two animal caretakers had not
placed a lock on the divider...".
"The prompt consideration of this matter by the University of Wisconsin -
Madison was consistent with the philosophy of institutional self-regulation.
Similarly, the actions taken to resolve the issue and prevent recurrence were
appropriate."
9S
12/11/2019
"... This Office understands that the SMPH IACUC determined that instances of
noncompliance occurred with respect to administration of a compound, fisetin, to
a group of mice prior to protocol approval.
"... OLAW understands that the University of Wisconsin-Madison has implemented
appropriate measures to correct and prevent recurrences of this problem and is
now compliant with provisions of the PHS Policy."
9T
12/16/2019
"... OLAW understands that a rhesus monkey escaped its cage because it had not
been properly locked. The monkey fought with another one and both sustained mild
injuries."
"... OLAW understands that measures have been implemented to correct and reduce
the liklihood of a recurrance of the problem."
9U
12/16/2019
"... OLAW understands that an infant rhesus monkey was given an expired
antibiotic for four days for diarhea."
"... OLAW understands that measures have been implemented to correct and reduce
the liklihood of a recurrance of the problem."
9V
3/2/2020
"... OLAW understands that mice were given an antibody not described in the approved protocol and two mice died and one required euthanasia."
"The corrective actions consisted of stopping administration of the antibody, amending the protocol to include the anitbody at a reduced dose from what had been been given, and retraining laboratory staff on protocol compliance.
"... OLAW understands that measures have been implemented to correct and prevent recurrance of this problem."
9W
3/10/2020
"... OLAW understands the following about the incidents and the corresponding corrective actions:
A transport cage was not fully secured on a lift which allowed the rhesus monkey to escape and fight with other monkeys resulting in injuries.
Corrective action: The injured animnals were treated and the lift was altered to make it more stable.
An animal care taker failed to provide water to a rhesus monkey on two consecutive days. No adverse clinical signs were noted.
Corrective action: The caretaker was retrained on appropriate provision of water."
"... OLAW understands that measures have been implemented to correct and prevent the liklihood of a recurrance of these problems."
9X
3/9/2020
[Duplicate of 9W]
9Y
3/13/2020
"The Office of Laboratory Animal Welfare (OLAW) acknowledges receipt o[-your February 26, 2020 letter reporting an instance of noncompliance with the PHS Policy on humane Care and Use of Laboratory Animals at the University of Wisconsin - Madison. According to the information provided, OLAW understands that 36 mice died after being infected with a wild-type herpes virus (HSV-l). It was determined that a mathematical error was made in the dosing calculations resulting in the animals receiving a higher dose than intended, The remaining 64 animals on the study were euthanized due to the compromised experiment. The animals were supported by an NW grant.
The lab has instituted new preventive measures wherein no single person can infect animals without confirming with the PI that their dosing calculations are correct and that the stocks of virus being used have been properly diluted."
9Z
5/8/2020
"OLAW understands that two marmosets were given an experimental drug orally although the approved protocol stated that the intravenous or intramuscular route would be used. [The drug was Tacrolimus. It was first approved in 1994. RB]
"OLAW understands that measures have been implimented to correct and prevent recurrance of this problem."
